GHK-CU Research Peptide.
What is GHK-CU?
GHK-Cu: The Copper Peptide for Regeneration
Skin Health Anti-Aging Wound Healing Hair Growth Tissue Repair
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding peptide found in human plasma, saliva, and urine.
It’s made up of three amino acids—glycine, histidine, and lysine—that bind with copper (Cu²⁺) to form a complex known for its role in tissue repair, skin remodeling, and overall regenerative signaling.
Originally identified in the 1970s by Dr. Loren Pickart, GHK-Cu has since become one of the most studied peptides in the context of skin quality, recovery processes, and age-related changes in tissue function.
Primary Applications
GHK-Cu dosage protocols utilize this naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) to support skin rejuvenation, wound healing, and tissue repair[1][2]. GHK-Cu stimulates collagen and elastin production, promotes angiogenesis, and delivers powerful antioxidant and anti-inflammatory benefits[3][4]. Human studies demonstrate improved skin thickness, reduced wrinkles, and enhanced dermal density with GHK-Cu application[2]. This educational protocol presents a once-daily subcutaneous approach using a practical dilution for clear insulin-syringe measurements.
Dosing & Administration
Protocol Overview
Concise summary of the once-daily regimen.
Goal: Support skin rejuvenation, collagen synthesis, wound healing, and anti-aging tissue repair[2][3].
Schedule: Daily subcutaneous injections, 5 days on / 2 days off, for 8–12 weeks.
Dose Range: 1–2 mg daily with gradual titration.
Reconstitution: 3.0 mL per 100 mg vial (~33.3 mg/mL) for accurate unit measurements.
Storage: Lyophilized frozen at −20 °C; reconstituted refrigerated; use within 30 days.
Dosing Protocol
Suggested daily titration approach.
Start: 1.0 mg daily for Weeks 1–4; increase to 1.5 mg for Weeks 5–8.
Target: 2.0 mg daily by Weeks 9–12.
Frequency: Once per day (subcutaneous), 5 days per week.
Cycle Length: 8–12 weeks; take 2–4 weeks off before repeating
Potential Benefits & Side Effects
Observations from preclinical and clinical literature.
Skin Rejuvenation: Clinical studies show increased skin thickness, improved dermal collagen density, and reduced wrinkle depth with GHK-Cu application[2].
Wound Healing: Promotes angiogenesis, granulation tissue formation, and accelerated wound closure in preclinical models[3][4].
Anti-Inflammatory: Suppresses pro-inflammatory cytokines (TNF-α, IL-6) and provides antioxidant protection[1][11].
Hair Growth: Observed to enlarge hair follicle size and increase growth rate in studies[2].
Safety Profile: Excellent tolerability with no serious adverse effects noted; extremely wide safety margin in toxicology studies[9][10].
Occasional mild injection-site reactions (transient redness or stinging) may occur with subcutaneous administration.
Important Note
This content is for educational purposes only and is not medical advice.